Nadeau Lab in the division of Immunology & Allergy

Nadeau Lab

Over recent years, there has been an increase in allergic disorders to epidemic proportions in children and adults. Many studies have determined that the immune system in patients with allergies (also called atopy), such as asthma, atopic dermatitis, food allergies, allergic rhinitis, allergic conjunctivitis and other atopic disorders, is overactive and skewed toward a certain subtype of immune cell called the Th2 cell. So far, there is a lack of understanding on how cells turn off this abnormal proliferation and activation of the Th2 cell. The Nadeau laboratory has found that a type of cell called the natural regulatory T cells (nTreg) can decrease Th2 cell overactivation in allergies and this leads to reversal or improvement of the allergic condition. By understanding how Treg work, we hope to establish new diagnostic and therapeutic approached to prevent and treat allergic conditions.

The Nadeau laboratory maintains a database and sample/tissue bank of healthy controls and patients treated at LPCH/Stanford Medical Center with allergic disorders.

There are three main foci of the laboratory: "Making and Breaking Immune Tolerance in Allergic Disorders"

  1. Pollution and Allergies and Regulatory T Cells
  2. Immunodeficiency and Regulatory T cells
  3. Food Allergy and Regulatory T cells

SAFAR patientThe Stanford Alliance for Food Allergy Research (SAFAR) is a worldwide leader in the study of food allergies. More »

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